Methylamine → HCID 68011887, compound

HRID 920970Notes

Reaction equation

HRID 920970 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[N:7]2[CH2:8][CH2:9][NH:10][CH2:11][C:6]2=[C:5]([C:12]([O-:14])=O)[N:4]=1.[CH3:17][NH2:18]>>[CH3:17][NH:18][C:12]([C:5]1[N:4]=[C:3]([C:2]([F:1])([F:16])[F:15])[N:7]2[CH2:8][CH2:9][NH:10][CH2:11][C:6]=12)=[O:14]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 86685642HCID 86685642, compound

Product 1

HCID 68011887HCID 68011887, compound

Conditions

Temperature
60 °C

Procedure

Methyl 3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxylate 3b (500 mg, 2 mmol) was dissolved in 8 mL of methylamine solution (20% to 30%) was added in a 20 mL sealed tube. After stirring at 60° C. for 6 hours, the reaction mixture was concentrated under reduced pressure to obtain the crude N-methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro imidazo[1,5-a]pyrazine-1-carboxamide 13a (498 mg) as a white solid. The product was used directly in the next reaction without purification.

Workup

  1. additionwas added in a 20 mL
  2. customsealed tube
  3. concentrationthe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-c9e27c0ca0884967b4a438c99cc41a76
Source dataset
uspto-grants-2016_03
Patent number
US09273052B2

Reaction notes

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