Hydrochloric Acid → HCID 86685647, compound

HRID 920985Notes

Reaction equation

HRID 920985 reaction equation
[CH3:1][N:2]([CH3:25])[C:3]([C:5]1[N:6]=[C:7]([C:21]([F:24])([F:23])[F:22])[N:8]2[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][C:9]=12)=[O:4].[ClH:26]>O1CCOCC1>[ClH:26].[CH3:1][N:2]([CH3:25])[C:3]([C:5]1[N:6]=[C:7]([C:21]([F:24])([F:22])[F:23])[N:8]2[CH2:13][CH2:12][NH:11][CH2:10][C:9]=12)=[O:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68011898HCID 68011898, compound

Product 1

HCID 86685647HCID 86685647, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Crude tert-butyl 1-(dimethylcarbamoyl)-3-(trifluoromethyl)-6,8-dihydro-5H-imidazo[1,5-c]pyrazine-7-carboxylate 22a (362 mg, 1 mmol) was dissolved in 3 mL of a 2 M solution of hydrogen chloride in 1,4-dioxane. After stirring for 12 hours, the reaction mixture was concentrated under reduced pressure to obtain crude N,N-dimethyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro imidazo[1,5-a]pyrazine-1-carboxamide hydrochloride 22b (262 mg) as a light yellow solid. The product was used directly in the next reaction without purification.

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-6d3ac7b75d1348bcb4305fe484d75ad1
Source dataset
uspto-grants-2016_03
Patent number
US09273052B2

Reaction notes

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