Potassium Carbonate → N-(cyclopropylmethyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide

HRID 920994Notes

Reaction equation

HRID 920994 reaction equation
Cl.[CH:2]1([CH2:5][NH:6][C:7]([C:9]2[N:10]=[C:11]([C:18]([F:21])([F:20])[F:19])[N:12]3[CH2:17][CH2:16][NH:15][CH2:14][C:13]=23)=[O:8])[CH2:4][CH2:3]1.C(=O)([O-])[O-].[K+].[K+]>ClCCl>[CH:2]1([CH2:5][NH:6][C:7]([C:9]2[N:10]=[C:11]([C:18]([F:19])([F:20])[F:21])[N:12]3[CH2:17][CH2:16][NH:15][CH2:14][C:13]=23)=[O:8])[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 86685650N-(cyclopropylmethyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydro imidazo[1,5-a]pyrazine-1-carboxamide hydrochloride

Product 1

HCID 68011901N-(cyclopropylmethyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamideYield 112.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

N-(cyclopropylmethyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide hydrochloride 24b (250 mg, 0.77 mmol) was dissolved in 10 mL of dichloromethane, followed by addition of potassium carbonate (320 mg, 2.30 mmol). After stirring for 4 hours, the reaction mixture was filtered and the filtrate was concentrated under reduced pressure to obtain crude N-(cyclopropylmethyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide 24c (250 mg) as a yellow solid. The product was used directly in the next reaction without purification.

Workup

  1. filtrationthe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-9cfd8df8bd854eabaaa57d9e669a35d5
Source dataset
uspto-grants-2016_03
Patent number
US09273052B2

Reaction notes

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