Hydrochloric Acid → 3,4-Diamino-6-tert-butylpyridine dihydrochloride

HRID 921039노트

반응식

HRID 921039 반응식
Br[C:2]1[CH:3]=[N:4][C:5]([C:9]([CH3:12])([CH3:11])[CH3:10])=[CH:6][C:7]=1[NH2:8].C1(N)C(F)=C(F)C(F)=C([NH2:22])C=1F.[ClH:25].Cl.Cl>C(O)C>[ClH:25].[ClH:25].[NH2:22][C:2]1[CH:3]=[N:4][C:5]([C:9]([CH3:12])([CH3:11])[CH3:10])=[CH:6][C:7]=1[NH2:8]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 679958335-Bromo-2-tert-butylpyridin-4-amine

생성물 1

HCID 679950033,4-Diamino-6-tert-butylpyridine dihydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Procedure analogous to 4) S18 using 22.9 g (100 mmol) of 3-bromo-4-amino-6-tert-butylpyridine (S40) instead of 29.5 g (100 mmol) of 2-(2-bromo-4-fluorophenyl)-D4-benzimidazole (S9). The crude product is converted into the dihydrochloride by dissolution in 100 ml of ethanol and introduction of gaseous hydrochloric acid. The crystals obtained in this way are filtered off with suction and dried in vacuo. Yield: 13.3 g (56 mmol), 56%. Purity: >95% according to 1H-NMR.

후처리

  1. customThe crystals obtained in this way
  2. filtrationare filtered off with suction
  3. customdried in vacuo

출처 및 근거

ORD 기록
ord-01d133d4a5f54ad1a0b62a16561e01c6
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09273080B2

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