反应详情

温度

100 °C

To a solution of 2-bromo-4-fluoro-1-(2-iodoethyl)benzene (2.23 g, 6.78 mmol) in toluene (15 ml) was added Ph3P (1.778 g, 6.78 mmol) and the mixture was heated at 100° C. for 16 h. The mixture was cooled to rt, solids were filtered and washed with toluene and ether, dried under high vac to afford (2-bromo-4-fluorophenethyl)triphenylphosphonium, iodide salt (3 g, 5.07 mmol, 74.8% yield) as white solid. 1H NMR (500 MHz, DMSO-d6) δ 8.01-7.87 (m, 9H), 7.85-7.77 (m, 6H), 7.66-7.51 (m, 1H), 7.35-7.24 (m, 1H), 7.20-7.07 (m, 1H), 3.93-3.80 (m, 2H), 3.07-2.86 (m, 2H).

1. temperatureThe mixture was cooled to rt
2. filtrationsolids were filtered
3. washwashed with toluene and ether
4. customdried under high vac