4-Anilino-2,5-dichloropyrimidine → 5-chloro-N2-[6-(dimethylphosphoryl)-2-methoxypyridin-3-yl]-N4-phenylpyrimidine-2,4-diamine

HRID 921330Notes

Reaction equation

HRID 921330 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:5]([Cl:15])=[CH:4][N:3]=1.[CH3:16][P:17]([C:20]1[N:25]=[C:24]([O:26][CH3:27])[C:23]([NH2:28])=[CH:22][CH:21]=1)([CH3:19])=[O:18]>>[Cl:15][C:5]1[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[N:7][C:2]([NH:28][C:23]2[C:24]([O:26][CH3:27])=[N:25][C:20]([P:17]([CH3:16])([CH3:19])=[O:18])=[CH:21][CH:22]=2)=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 187680474-Anilino-2,5-dichloropyrimidineHCID 67052694(5-Amino-6-methoxypyridin-2-yl)dimethylphosphine oxide

Product 1

HCID 681569075-chloro-N2-[6-(dimethylphosphoryl)-2-methoxypyridin-3-yl]-N4-phenylpyrimidine-2,4-diamine

Procedure

This compound can be prepared as in Example 32 by reacting 2,5-dichloro-N-phenylpyrimidin-4-amine with 6-(Dimethylphosphoryl)-2-methoxypyridin-3-ylamine (prepared in Example 32)

Workup

  1. customThis compound can be prepared as in Example 32

Sources & evidence

ORD record
ord-76120a5edab24a31baea864262e52fcb
Source dataset
uspto-grants-2016_03
Patent number
US09273077B2

Reaction notes

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