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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 921330Generated: October 30, 2026

4-Anilino-2,5-dichloropyrimidine → 5-chloro-N2-[6-(dimethylphosphoryl)-2-methoxypyridin-3-yl]-N4-phenylpyrimidine-2,4-diamine

https://huagongshe.com/reaction/921330

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Anilino-2,5-dichloropyrimidineHCID 18768047—
Reactant(5-Amino-6-methoxypyridin-2-yl)dimethylphosphine oxideHCID 67052694—
Product5-chloro-N2-[6-(dimethylphosphoryl)-2-methoxypyridin-3-yl]-N4-phenylpyrimidine-2,4-diamineHCID 68156907—

Reaction Steps

This compound can be prepared as in Example 32 by reacting 2,5-dichloro-N-phenylpyrimidin-4-amine with 6-(Dimethylphosphoryl)-2-methoxypyridin-3-ylamine (prepared in Example 32)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09273077B2
Source datasetuspto-grants-2016_03
ORD IDord-76120a5edab24a31baea864262e52fcb
Source noteuspto-grants-2016_03