2,6-Dimethoxypyridin-3-amine → 5-chloro-N2-[6-(dimethylphosphoryl)-2-methoxypyridin-3-yl]-N4-[4-(dimethylphosphoryl)phenyl]pyrimidine-2,4-diamine

HRID 921334Notes

Reaction equation

HRID 921334 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([P:15]([CH3:18])([CH3:17])=[O:16])=[CH:11][CH:10]=2)[C:5]([Cl:19])=[CH:4][N:3]=1.[CH3:20][O:21][C:22]1[C:27]([NH2:28])=[CH:26][CH:25]=[C:24](OC)[N:23]=1>>[Cl:19][C:5]1[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([P:15]([CH3:18])([CH3:17])=[O:16])=[CH:11][CH:10]=2)=[N:7][C:2]([NH:28][C:27]2[C:22]([O:21][CH3:20])=[N:23][C:24]([P:15]([CH3:17])([CH3:12])=[O:16])=[CH:25][CH:26]=2)=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 5930052,6-Dimethoxypyridin-3-amineHCID 86668790HCID 86668790, compound

Product 1

HCID 866687975-chloro-N2-[6-(dimethylphosphoryl)-2-methoxypyridin-3-yl]-N4-[4-(dimethylphosphoryl)phenyl]pyrimidine-2,4-diamine

Procedure

This compound can be prepared as in Example 32 by reacting 2,5-dichloro-N-[4-(dimethylphosphoryl)phenyl]pyrimidin-4-amine with 2,6-Dimethoxypyridin-3-amine.

Workup

  1. customThis compound can be prepared as in Example 32

Sources & evidence

ORD record
ord-fb6f1f8c20264d79a27e6fc93e4e617c
Source dataset
uspto-grants-2016_03
Patent number
US09273077B2

Reaction notes

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