3,5-Dimethylaniline → HCID 86668820, compound

HRID 921436Notes

Reaction equation

HRID 921436 reaction equation
Cl[C:2]1[N:7]=[C:6]([Cl:8])[N:5]=[C:4]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([P:16]([CH3:19])([CH3:18])=[O:17])=[CH:12][CH:11]=2)[N:3]=1.C(N(CC)CC)C.[CH3:27][C:28]1[CH:29]=[C:30]([CH:32]=[C:33]([CH3:35])[CH:34]=1)[NH2:31]>C(O)C>[Cl:8][C:6]1[N:7]=[C:2]([NH:31][C:30]2[CH:32]=[C:33]([CH3:35])[CH:34]=[C:28]([CH3:27])[CH:29]=2)[N:3]=[C:4]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([P:16]([CH3:19])([CH3:18])=[O:17])=[CH:12][CH:11]=2)[N:5]=1

Participants

5

Reactant 3

HCID 79493,5-DimethylanilineHCID 8471TriethylamineHCID 86668818HCID 86668818, compound

Product 1

HCID 86668820HCID 86668820, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 4,6-dichloro-N-[4-(dimethylphosphoryl)phenyl]-1,3,5-triazin-2-amine (prepared as in Example 102: 0.12 mmol) in 2 mL of ethanol is added 50 L of triethylamine and 3,5-dimethylaniline (24 mg, 0.12 mmol). The mixture is microwaved at 120 degrees until formation of the desired compound. The reaction mixture is filtered through a syringe filter and purified by prep-HPLC.

Sources & evidence

ORD record
ord-3b9fa6dc6bf84eafa082af83445b111f
Source dataset
uspto-grants-2016_03
Patent number
US09273077B2

Reaction notes

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