Silane, tris(1-methylethyl)- → HCID 86685028, compound

HRID 921515Notes

Reaction equation

HRID 921515 reaction equation
C([SiH](C(C)C)C(C)C)(C)C.[Br-:11].C(OC([NH:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][P+:26]([C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1)([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)=O)(C)(C)C.[C:45]([OH:51])([C:47]([F:50])([F:49])[F:48])=[O:46].C(Cl)Cl>>[Br-:11].[NH3+:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][P+:26]([C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1)([C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1.[Br-:11].[C:45]([OH:51])([C:47]([F:50])([F:49])[F:48])=[O:46]

Participants

4

Reactant 3

HCID 138754Silane, tris(1-methylethyl)-HCID 21863450Trifluoroacetic acid methylene chlorideHCID 86685029HCID 86685029, compound

Product 1

HCID 86685028HCID 86685028, compound

Procedure

A solution of TFA/CH2Cl2 (1:1, 50 ml) containing triisoproylsilane (0.2 ml) was added to (6-((tert-butoxycarbonyl)amino)hexyl)triphenylphosphonium bromide (8.0 g). The mixture was stirred for 2 hours. After removal of the solvent, the compound was dried over a vacuum and directly used in next step.

Workup

  1. customAfter removal of the solvent
  2. customthe compound was dried over a vacuum

Sources & evidence

ORD record
ord-6db10d863df04b65bbb698c62b4e7e70
Source dataset
uspto-grants-2016_03
Patent number
US09273343B2

Reaction notes

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