Sodium Hydroxide → HCID 178506294, compound

HRID 921519Notes

Reaction equation

HRID 921519 reaction equation
P(Cl)(Cl)([Cl:3])=O.[F:6][C:7]([F:19])([F:18])[C:8]1[C:16]2[C:11](=[N+:12]([O-])[CH:13]=[CH:14][CH:15]=2)[NH:10][N:9]=1.[OH-].[Na+]>>[Cl:3][C:15]1[CH:14]=[CH:13][N:12]=[C:11]2[NH:10][N:9]=[C:8]([C:7]([F:19])([F:18])[F:6])[C:16]=12

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 24813Phosphorus oxychlorideHCID 178526242HCID 178526242, compound

Product 1

HCID 178506294HCID 178506294, compoundYield 27%

Conditions

Temperature
100 °C

Procedure

Phosphorus oxychloride (76.4 g) was gradually added to compound (1b) (33.2 g), followed by stirring at 100° C. for 1 hr. The reaction solution was poured into ice water, and sodium hydroxide was added thereto to adjust the pH to 10. The precipitate was collected by filtration to obtain compound (1c) (9.76 g, 270) as a light pink solid.

Workup

  1. additionwas added
  2. filtrationThe precipitate was collected by filtration

Sources & evidence

ORD record
ord-dcadbac53b264c4d83b9de09cc20cd6c
Source dataset
uspto-grants-2016_03
Patent number
US09273045B2

Reaction notes

Loading…