Hydrazine hydrate (1:1) → HCID 55281378, compound

HRID 921573Notes

Reaction equation

HRID 921573 reaction equation
O.[NH2:2][NH2:3].F[C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[CH:7][C:6]=1[CH3:13]>O>[NH:2]([C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[CH:7][C:6]=1[CH3:13])[NH2:3]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 27791804-Fluoro-3-methylbenzonitrile

Product 1

HCID 55281378HCID 55281378, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

Hydrazine monohydrate (180 mL) was added to 4-fluoro-3-methylbenzonitrile (5.0 g), followed by stirring at 100° C. for 4 hr. Water was added to the reaction solution, and the precipitate was collected by filtration and was dried under reduced pressure to obtain compound (154a) (4.33 g, 79%).

Workup

  1. filtrationthe precipitate was collected by filtration
  2. customwas dried under reduced pressure

Sources & evidence

ORD record
ord-c086fe6a2dd44cdeb7b3d99f417b95d0
Source dataset
uspto-grants-2016_03
Patent number
US09273045B2

Reaction notes

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