1-Methylpiperazine → HCID 86708524, compound

HRID 921660Notes

Reaction equation

Br[C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([NH:13][C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[C:11]=1[Cl:12])[C:5]([O:7][CH3:8])=[O:6].[CH3:21][N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1>>[C:17]([O:16][C:14]([NH:13][C:10]1[CH:9]=[C:4]([CH:3]=[C:2]([N:25]2[CH2:26][CH2:27][N:22]([CH3:21])[CH2:23][CH2:24]2)[C:11]=1[Cl:12])[C:5]([O:7][CH3:8])=[O:6])=[O:15])([CH3:20])([CH3:19])[CH3:18]

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 86708461HCID 86708461, compound2×

Product 1

HCID 86708524HCID 86708524, compound

Procedure

Methyl 3-((tert-butoxycarbonyl)amino)-4-chloro-5-(4-methylpiperazin-1-yl)benzoate was prepared starting from methyl 3-bromo-5-((tert-butoxycarbonyl)amino)-4-chlorobenzoate (Intermediate 3) and 1-methylpiperazine according to procedure for example 1A

Sources & evidence

ORD record: ord-81bc35ce92f24733b64a23c9932065c5
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09273057B2

Reaction notes

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