HCID 45116038, compound → HCID 130624317, compound

A solution of LiAIH4 in THF (2M in THF, 20 ml, 40 mmol) was added slowly to a solution of (+/−)-(7R,8aS)-7-hydroxyhexahydropyrrolo[1,2-a]pyrazine-1,4-dione (prepared according to a published literature procedure: Pharmaceutical Chemistry Journal, Vol 46, No. 2, 96 (2012), 2 g, 11.75 mmol) in THF (60 mL) and the resulting mixture was heated at reflux for 5 h. The reaction was quenched with careful addition of 0.6 ml of water, 0.6 ml of 15% NaOH and 1.2 ml water. Celite and anhydrous magnesium sulfate were then added and the mixture stirred for 1 h. The mixture was filtered and the filtrate was concentrated to give (+/−)-(7R)-octahydropyrrolo[1,2-a]pyrazin-7-ol (0.925 g) which was used without further purification.

1. customprepared
2. temperatureat reflux for 5 h
3. customThe reaction was quenched with careful addition of 0.6 ml of water, 0.6 ml of 15% NaOH and 1.2 ml water
4. additionCelite and anhydrous magnesium sulfate were then added
5. filtrationThe mixture was filtered
6. concentrationthe filtrate was concentrated

ORD record

ord-ab49806f628b410785ce64b0dae23fc2

Source dataset

uspto-grants-2016_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09273057B2