反应详情

Tert-butyl (2-chloro-5-cyano-3-(3-(4-methylpiperazin-1-yl)propyl)phenyl)carbamate (49 mg, 0.125 mmol) was taken up in DCM (0.8 mL) and TFA (0.192 mL, 2.494 mmol) was added. The reaction was stirred at room temperature for 1 h. The solvent was removed in vacuo and the material azeotroped 2× with toluene. The material was dried under vacuum overnight. 3-amino-4-chloro-5-(3-(4-methylpiperazin-1-yl)propyl)benzonitrile, TFA (88 mg) was obtained as an off-white solid.

1. customThe solvent was removed in vacuo
2. customthe material azeotroped 2× with toluene
3. customThe material was dried under vacuum overnight