反应详情

To a solution of tert-butyl 2-methyl-1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate (315 mg, 1.174 mmol) in DCM (5 mL) was added TFA (1.718 mL, 22.30 mmol) and the mixture was stirred at room temperature for 2 h. The reaction was concentrated under reduced pressure to obtain crude and purified by SCX cartridge, loading with MeOH, washed with additional MeOH. Product was recovered eluting with 2M NH3 in MeOH. Solvent evaporation gave 2-methyl-2,8-diazaspiro[4.5]decan-1-one (177 mg).

1. concentrationThe reaction was concentrated under reduced pressure
2. customto obtain crude
3. custompurified by SCX cartridge
4. washwashed with additional MeOH
5. customProduct was recovered
6. washeluting with 2M NH3 in MeOH
7. customSolvent evaporation