tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate → 2-((2-Chloro-5-cyano-3-(2,7-diazaspiro[3.5]nonan-7-yl)phenyl)amino)-4-(cyclopropylamino)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile

HRID 921954Notes

Reaction equation

HRID 921954 reaction equation
[CH2:1]1[C:4]2([CH2:9][CH2:8][NH:7][CH2:6][CH2:5]2)[CH2:3][N:2]1C(OC(C)(C)C)=O.[Cl:17][C:18]1[C:23](N2CCNCC2)=[CH:22][C:21]([C:30]#[N:31])=[CH:20][C:19]=1[NH:32][C:33]1[N:38]=[C:37]([N:39]([CH:49]2[CH2:51][CH2:50]2)CC2C=CC(OC)=CC=2)[C:36]2=[N:52][CH:53]=[C:54]([C:55]#[N:56])[N:35]2[N:34]=1>>[Cl:17][C:18]1[C:23]([N:7]2[CH2:6][CH2:5][C:4]3([CH2:1][NH:2][CH2:3]3)[CH2:9][CH2:8]2)=[CH:22][C:21]([C:30]#[N:31])=[CH:20][C:19]=1[NH:32][C:33]1[N:38]=[C:37]([NH:39][CH:49]2[CH2:51][CH2:50]2)[C:36]2=[N:52][CH:53]=[C:54]([C:55]#[N:56])[N:35]2[N:34]=1

Participants

3

Reactant 2

HCID 23282935tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylateHCID 867084922-((2-Chloro-5-cyano-3-(piperazin-1-yl)phenyl)amino)-4-(cyclopropyl(4-methoxybenzyl)amino)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile

Product 1

HCID 899224182-((2-Chloro-5-cyano-3-(2,7-diazaspiro[3.5]nonan-7-yl)phenyl)amino)-4-(cyclopropylamino)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile

Procedure

The title compound was prepared from tert-butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate using a method to prepare Intermediate 11 and method analogous to that used to prepare Example 1.

Workup

  1. customto prepare Example 1

Sources & evidence

ORD record
ord-6f63c24d56084bb59815d5ecc8d45a3b
Source dataset
uspto-grants-2016_03
Patent number
US09273057B2

Reaction notes

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