Clofibric Acid → HCID 178443016, compound

HRID 921994Notes

Reaction equation

HRID 921994 reaction equation
[C:1]([O-:10])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4].[CH2:11]([N+:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26].[CH3:33][C:34]([O:39][C:40]1[CH:41]=[CH:42][C:43]([Cl:46])=[CH:44][CH:45]=1)([C:36]([OH:38])=[O:37])[CH3:35]>>[C:1]([O-:10])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4].[CH2:11]([N+:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26].[CH3:1][CH2:2][O:37][C:36]([C:34]([O:39][C:40]1[CH:45]=[CH:44][C:43]([Cl:46])=[CH:42][CH:41]=1)([CH3:33])[CH3:35])=[O:38]

Participants

3

Reactant 2

HCID 2797Clofibric AcidHCID 178443018HCID 178443018, compound

Product 1

HCID 178443016HCID 178443016, compound

Procedure

Cetylpyridinium salicylate (2 mmol) and clofibric acid (2 mmol) were grinded for 15 minutes in a mortar until a colourless cream was obtained. Identity and purity of the obtained product was confirmed via 1H NMR. 1H-NMR (300 MHz, d6-DMSO) δ(ppm)=9.13 (d, J=6.3 Hz, 2H), 8.60 (t, J=7.7 Hz, 1H), 8.16 (t, J=7.0 Hz, 2H), 7.67 (d, 8.0 Hz, 1H), 7.28 (d, J=9.1 Hz, 2H), 7.14 (t, J=6.7, 1H), 6.84 ((d, J=9.1 Hz, 2H), 6.61 (m, 2H), 4.59 (t, J=7.5 Hz, 2H), 1.89 (m, 2H), 1.47 (s, 6H), 1.22 (s, 27H), 0.84 (t, J=7.0 Hz, 3H). mp 8° C., T5%onset 197° C.

Workup

  1. customwas obtained
  2. custommp 8° C., T5%onset 197° C.

Sources & evidence

ORD record
ord-e640c1fe1e4f4c9b9f5ec2768df5ef9e
Source dataset
uspto-grants-2016_03
Patent number
US09278134B2

Reaction notes

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