反应详情

Crude (E)-7-(2,5-dimethoxy-3,4,6-trimethylphenyl)-5-methylhept-5-enenitrile in MeOH (3 mL) was cooled to 0° C. and treated with NaBH4 (64.3 mg, 1.74 mmol), which gave immediate effervescence. After 12 h, H2O (10 mL) was added (caution: copious gas evolution), MTBE (10 mL) was added, separated and the aqueous phase extracted with MTBE (3×10 mL). The combined organics were washed with H2O (10 mL), brine (10 mL), dried over Na2SO4 and concentrated to give (E)-7-(2,5-dimethoxy-3,4,6-trimethylphenyl)-5-methylhept-5-en-1-ol as a pale yellow oil.

1. customgave immediate effervescence
2. additionwas added
3. customseparated
4. extractionthe aqueous phase extracted with MTBE (3×10 mL)
5. washThe combined organics were washed with H2O (10 mL), brine (10 mL)
6. dry with materialdried over Na2SO4
7. concentrationconcentrated