Potassium Carbonate → Aripiprazole

HRID 922167Notes

Reaction equation

HRID 922167 reaction equation
C(=O)([O-])[O-].[K+].[K+].Cl[CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:22]=[C:21]2[C:16]([CH2:17][CH2:18][C:19](=[O:23])[NH:20]2)=[CH:15][CH:14]=1.Cl.[Cl:25][C:26]1[C:31]([Cl:32])=[CH:30][CH:29]=[CH:28][C:27]=1[N:33]1[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1>O>[CH:29]1[CH:28]=[C:27]([N:33]2[CH2:38][CH2:37][N:36]([CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]3[CH:14]=[CH:15][C:16]4[CH2:17][CH2:18][C:19](=[O:23])[NH:20][C:21]=4[CH:22]=3)[CH2:35][CH2:34]2)[C:26]([Cl:25])=[C:31]([Cl:32])[CH:30]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 104674677-(4-Chlorobutoxy)-1,2,3,4-tetrahydroquinolin-2-oneHCID 116303721-(2,3-Dichlorophenyl)piperazine hydrochloride

Product 1

HCID 60795AripiprazoleYield 75.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Potassium carbonate (8.39 g) was dissolved in water (140 mL), followed by the addition of 7-(4-chlorobutoxy)-3,4-dihydrocarbostyril (19.4 g) and 1-(2,3-dichlorophenyl)piperazine monohydrochloride (16.2 g) thereto. The mixture was refluxed under stirring for about 3 hours. After reaction, the resulting mixture was cooled, and precipitated crystals were filtered. The crystals were dissolved in ethyl acetate (350 mL), and about 210 mL of water/ethyl acetate azeotrope was distilled under reflux. The remaining solution was cooled, and precipitated crystals were filtered. The thus-obtained crystals were dried at 60° C. for 14 hours, thereby obtaining 20.4 g of crude aripiprazole (yield: 74.2%).

Workup

  1. temperatureThe mixture was refluxed
  2. customAfter reaction
  3. temperaturethe resulting mixture was cooled
  4. customprecipitated crystals
  5. filtrationwere filtered
  6. dissolutionThe crystals were dissolved in ethyl acetate (350 mL)
  7. distillationabout 210 mL of water/ethyl acetate azeotrope was distilled
  8. temperatureunder reflux
  9. temperatureThe remaining solution was cooled
  10. customprecipitated crystals
  11. filtrationwere filtered
  12. customThe thus-obtained crystals were dried at 60° C. for 14 hours

Sources & evidence

ORD record
ord-947a69e652f144cfabd426ecae67b4fd
Source dataset
uspto-grants-2016_03
Patent number
US09278934B2

Reaction notes

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