Methyl 3-cyano-3-(4-hydroxyphenyl)propanoate → 3-Cyano-3-{4-[(4-{[(2E)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid
Reaction equation
[CH3:1][O:2]/[N:3]=[C:4](/[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)\[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][OH:14])=[CH:9][CH:8]=1.[C:21]([CH:23]([C:29]1[CH:34]=[CH:33][C:32](O)=[CH:31][CH:30]=1)[CH2:24][C:25]([O:27]C)=[O:26])#[N:22]>>[C:21]([CH:23]([C:29]1[CH:34]=[CH:33][C:32]([O:14][CH2:13][C:10]2[CH:11]=[CH:12][C:7]([O:6][CH2:5]/[C:4](=[N:3]\[O:2][CH3:1])/[C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:8][CH:9]=2)=[CH:31][CH:30]=1)[CH2:24][C:25]([OH:27])=[O:26])#[N:22]Participants
3
Procedure
Compound 16 was synthesized from (4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}phenyl) methanol (0.264 g, 0.98 mmol) and methyl 3-cyano-3-(4-hydroxyphenyl)propanoate (0.2 g, 0.98 mmol) by following the procedure described in Scheme 5 (0.15 g, yield: 34.7%); Purity: 98.2%:
Sources & evidence
- ORD record
- ord-49bb2742698040bbafe26fba2db9d1a9
- Source dataset
- uspto-grants-2016_03
- Patent number
- US09278915B2
Reaction notes
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