Methyl 3-cyano-3-(4-hydroxyphenyl)propanoate → 3-Cyano-3-{4-[(4-{[(2E)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid

Participants

Role	Name	HCID	Charge
Reactant	Methyl 3-cyano-3-(4-hydroxyphenyl)propanoate	HCID 66685605	—
Reactant	(4-{[(2E)-2-(methoxyimino)-2-phenylethyl]oxy}phenyl)methanol	HCID 86695770	—
Product	3-Cyano-3-{4-[(4-{[(2E)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid	HCID 56639930	34.7%

Reaction Steps

Compound 16 was synthesized from (4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}phenyl) methanol (0.264 g, 0.98 mmol) and methyl 3-cyano-3-(4-hydroxyphenyl)propanoate (0.2 g, 0.98 mmol) by following the procedure described in Scheme 5 (0.15 g, yield: 34.7%); Purity: 98.2%:

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09278915B2
Source dataset	uspto-grants-2016_03
ORD ID	ord-49bb2742698040bbafe26fba2db9d1a9
Source note	uspto-grants-2016_03