Ethyl 2-(4-hydroxyphenyl)cyclopropane-1-carboxylate → 2-[4-[[4-[(2Z)-2-(4-cyanophenyl)-2-methoxyiminoethoxy]phenyl]methoxy]phenyl]cyclopropane-1-carboxylic acid
Reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:10][CH:9]2[C:11]([O:13]CC)=[O:12])=[CH:4][CH:3]=1.Br[CH2:17][C:18]1[CH:37]=[CH:36][C:21]([O:22][CH2:23]/[C:24](/[C:28]2[CH:35]=[CH:34][C:31]([C:32]#[N:33])=[CH:30][CH:29]=2)=[N:25]\[O:26][CH3:27])=[CH:20][CH:19]=1>>[C:32]([C:31]1[CH:30]=[CH:29][C:28](/[C:24](=[N:25]/[O:26][CH3:27])/[CH2:23][O:22][C:21]2[CH:36]=[CH:37][C:18]([CH2:17][O:1][C:2]3[CH:3]=[CH:4][C:5]([CH:8]4[CH2:10][CH:9]4[C:11]([OH:13])=[O:12])=[CH:6][CH:7]=3)=[CH:19][CH:20]=2)=[CH:35][CH:34]=1)#[N:33]Participants
3
Procedure
Compound 45 was prepared from ethyl 2-(4-hydroxyphenyl)cyclopropanecarboxylate (0.1 g, 0.48 mmol), and 4-{(1Z)-2-[4-(bromomethyl) phenoxy]-N-methoxyethanimidoyl}benzonitrile (0.175 g, 0.48 mmol) by following the procedure described in scheme 17.
Sources & evidence
- ORD record
- ord-bc6f29332dc746a899f67042bc4f773f
- Source dataset
- uspto-grants-2016_03
- Patent number
- US09278915B2
Reaction notes
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