Sodium Hydroxide → sodium 3-cyano-3-[4-[[4-[(2Z)-2-(3-fluorophenyl)-2-methoxyiminoethoxy]phenyl]methoxy]phenyl]propanoate

HRID 922227Notes

Reaction equation

HRID 922227 reaction equation
[C:1]([CH:3]([C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:23]/[C:24](/[C:28]3[CH:33]=[CH:32][CH:31]=[C:30]([F:34])[CH:29]=3)=[N:25]\[O:26][CH3:27])=[CH:18][CH:17]=2)=[CH:10][CH:9]=1)[CH2:4][C:5]([OH:7])=[O:6])#[N:2].[OH-].[Na+:36]>>[C:1]([CH:3]([C:8]1[CH:9]=[CH:10][C:11]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:23]/[C:24](/[C:28]3[CH:33]=[CH:32][CH:31]=[C:30]([F:34])[CH:29]=3)=[N:25]\[O:26][CH3:27])=[CH:18][CH:17]=2)=[CH:12][CH:13]=1)[CH2:4][C:5]([O-:7])=[O:6])#[N:2].[Na+:36]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 566401413-cyano-3-[4-[[4-[(2Z)-2-(3-fluorophenyl)-2-methoxyiminoethoxy]phenyl]methoxy]phenyl]propanoic acid

Product 1

HCID 89790380sodium 3-cyano-3-[4-[[4-[(2Z)-2-(3-fluorophenyl)-2-methoxyiminoethoxy]phenyl]methoxy]phenyl]propanoateYield 71.59%

Procedure

Compound 55 was synthesized from 3-cyano-3-{4-[(4-{[(2Z)-2-(3-fluorophenyl)-2-(methoxyimino)ethyl]oxy}benzyl)oxy]phenyl}propanoic acid (0.55 g, 1.2 mmol) and sodium hydroxide (0.092 g, 2.3 mmol) by following the procedure described in scheme 12 (0.4 g, yield: 71.59%); Purity: 96.74%.

Sources & evidence

ORD record
ord-73b85e1a6bc1482dbc8a3d2ccd6b70c4
Source dataset
uspto-grants-2016_03
Patent number
US09278915B2

Reaction notes

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