Sodium Hydroxide → sodium 2-[4-[[4-[(2Z)-2-methoxyimino-2-(4-methoxyphenyl)ethoxy]phenyl]methoxy]phenyl]cyclopropane-1-carboxylate

HRID 922229Notes

Reaction equation

[CH3:1][O:2]/[N:3]=[C:4](/[C:27]1[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=1)\[CH2:5][O:6][C:7]1[CH:26]=[CH:25][C:10]([CH2:11][O:12][C:13]2[CH:18]=[CH:17][C:16]([CH:19]3[CH2:21][CH:20]3[C:22]([OH:24])=[O:23])=[CH:15][CH:14]=2)=[CH:9][CH:8]=1.[OH-].[Na+:36]>>[CH3:1][O:2]/[N:3]=[C:4](/[C:27]1[CH:28]=[CH:29][C:30]([O:33][CH3:34])=[CH:31][CH:32]=1)\[CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]([CH2:11][O:12][C:13]2[CH:18]=[CH:17][C:16]([CH:19]3[CH2:21][CH:20]3[C:22]([O-:24])=[O:23])=[CH:15][CH:14]=2)=[CH:25][CH:26]=1.[Na+:36]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 566402782-[4-[[4-[(2Z)-2-methoxyimino-2-(4-methoxyphenyl)ethoxy]phenyl]methoxy]phenyl]cyclopropane-1-carboxylic acid

Product 1

HCID 87111469sodium 2-[4-[[4-[(2Z)-2-methoxyimino-2-(4-methoxyphenyl)ethoxy]phenyl]methoxy]phenyl]cyclopropane-1-carboxylateYield 27.84%

Procedure

Compound 57 was synthesized from 2-{4-[(4-{[(2Z)-2-(methoxyimino)-2-(4-methoxyphenyl)ethyl]oxy}benzyl)oxy]phenyl}cyclopropanecarboxylic acid (0.08 g, 0.2 mmol) and sodium hydroxide (0.013 g, 0.3 mmol) by following the procedure described in scheme 12 (0.022 g, yield: 27.84%); Purity: 98.61%.

Sources & evidence

ORD record: ord-0830c71004584692ab51e513c44d8adc
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09278915B2

Reaction notes

Loading…