HCID 66686186, compound → HCID 88581364, compound

HRID 922231Notes

Reaction equation

HRID 922231 reaction equation
[CH3:1][O:2]/[N:3]=[C:4](/[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)\[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][OH:14])=[CH:9][CH:8]=1.[C:21]([C:23]([C:31]1[CH:36]=[CH:35][C:34](O)=[CH:33][CH:32]=1)([CH3:30])[CH2:24][C:25]([O:27]CC)=[O:26])#[N:22]>>[C:21]([C:23]([C:31]1[CH:36]=[CH:35][C:34]([O:14][CH2:13][C:10]2[CH:11]=[CH:12][C:7]([O:6][CH2:5]/[C:4](=[N:3]\[O:2][CH3:1])/[C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:8][CH:9]=2)=[CH:33][CH:32]=1)([CH3:30])[CH2:24][C:25]([OH:27])=[O:26])#[N:22]

Participants

3

Reactant 2

HCID 66686186HCID 66686186, compoundHCID 86695770(4-{[(2E)-2-(methoxyimino)-2-phenylethyl]oxy}phenyl)methanol

Product 1

HCID 88581364HCID 88581364, compoundYield 57.47%

Procedure

Compound 59 was synthesized from (1Z)-2-[4-(hydroxymethyl)phenoxy]-1-phenylethanone O-methyloxime (2.34 g, 8.66 mmol) and ethyl 3-cyano-3-(4-hydroxyphenyl)butanoate (2.4 g, 9.6 mmol) by following the procedure described in scheme 18 (0.15 g, yield: 57.47%); Purity: 98.34%.

Sources & evidence

ORD record
ord-c9e9a6ff07714dc9be8be06676b30903
Source dataset
uspto-grants-2016_03
Patent number
US09278915B2

Reaction notes

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