HCID 66686187, compound → HCID 87111511, compound

HRID 922233Notes

Reaction equation

HRID 922233 reaction equation
[CH3:1][O:2]/[N:3]=[C:4](/[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)\[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][OH:14])=[CH:9][CH:8]=1.[C:21]([CH:23]([C:29]1[CH:34]=[CH:33][C:32](O)=[CH:31][C:30]=1[CH3:36])[CH2:24][C:25]([O:27]C)=[O:26])#[N:22]>>[C:21]([CH:23]([C:29]1[CH:34]=[CH:33][C:32]([O:14][CH2:13][C:10]2[CH:11]=[CH:12][C:7]([O:6][CH2:5]/[C:4](=[N:3]\[O:2][CH3:1])/[C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:8][CH:9]=2)=[CH:31][C:30]=1[CH3:36])[CH2:24][C:25]([OH:27])=[O:26])#[N:22]

Participants

3

Reactant 2

HCID 66686187HCID 66686187, compoundHCID 86695770(4-{[(2E)-2-(methoxyimino)-2-phenylethyl]oxy}phenyl)methanol

Product 1

HCID 87111511HCID 87111511, compoundYield 95.69%

Procedure

Compound 62 was synthesized from (1Z)-2-[4-(hydroxymethyl)phenoxy]-1-phenylethanone O-methyloxime (0.5 g, 1.85 mmol) and methyl 3-cyano-3-(4-hydroxy-2-methylphenyl)propanoate (0.404 g, 1.85 mmol) by following the procedure described in scheme 18 (0.65 g, yield: 95.69%); Purity: 93.64%.

Sources & evidence

ORD record
ord-73e2ee221a644a4e8c6870b0060f669f
Source dataset
uspto-grants-2016_03
Patent number
US09278915B2

Reaction notes

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