反应详情

A mixture of the obtained 4-(chloromethyl)-7-hydroxy-2H-chromen-2-one (21.0 g, 21.0 mmol) and 1 M aqueous sodium hydroxide solution (1 L) was stirred at reflux for 2 h. The reaction mixture was acidified with concentrated sulfuric acid and extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous sodium sulphate and concentrated to give (6-Hydroxy-1-benzofuran-3-yl)acetic acid (18.0 g, 93.75%).

1. temperatureat reflux for 2 h
2. extractionextracted with ethyl acetate
3. washThe extract was washed with brine
4. dry with materialdried over anhydrous sodium sulphate
5. concentrationconcentrated