Sulfuric Acid → 2-(6-Hydroxy-1-benzofuran-3-yl)acetic acid

HRID 922250노트

반응식

HRID 922250 반응식
Cl[CH2:2][C:3]1[C:12]2[C:7](=[CH:8][C:9]([OH:13])=[CH:10][CH:11]=2)[O:6][C:5](=[O:14])[CH:4]=1.[OH-].[Na+].S(=O)(=O)(O)[OH:18]>>[OH:13][C:9]1[CH:10]=[CH:11][C:12]2[C:3]([CH2:4][C:5]([OH:14])=[O:18])=[CH:2][O:6][C:7]=2[CH:8]=1

참가 물질

4

반응물 3

HCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 53988464-(chloromethyl)-7-hydroxy-2H-chromen-2-one

생성물 1

HCID 21109152-(6-Hydroxy-1-benzofuran-3-yl)acetic acid수율 93.75%

실험 절차

A mixture of the obtained 4-(chloromethyl)-7-hydroxy-2H-chromen-2-one (21.0 g, 21.0 mmol) and 1 M aqueous sodium hydroxide solution (1 L) was stirred at reflux for 2 h. The reaction mixture was acidified with concentrated sulfuric acid and extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous sodium sulphate and concentrated to give (6-Hydroxy-1-benzofuran-3-yl)acetic acid (18.0 g, 93.75%).

후처리

  1. temperatureat reflux for 2 h
  2. extractionextracted with ethyl acetate
  3. washThe extract was washed with brine
  4. dry with materialdried over anhydrous sodium sulphate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-8afc4a7fd3204a3387200e8307303e80
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09278915B2

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