HCID 56640644, compound → HCID 56640713, compound

HRID 922286Notes

Reaction equation

HRID 922286 reaction equation
C(C[O:4][C:5]1[CH:10]=[C:9]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH2:20]/[C:21](=[N:28]\[O:29][CH3:30])/[C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:15][CH:14]=2)[CH:8]=[CH:7][C:6]=1[CH2:31][CH2:32][C:33]([O:35]CC)=[O:34])#N>[Pd]>[OH:4][C:5]1[CH:10]=[C:9]([O:11][CH2:12][C:13]2[CH:14]=[CH:15][C:16]([O:19][CH2:20]/[C:21](=[N:28]\[O:29][CH3:30])/[C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:17][CH:18]=2)[CH:8]=[CH:7][C:6]=1[CH2:31][CH2:32][C:33]([OH:35])=[O:34]

Participants

3

Reactant 1

HCID 56640644HCID 56640644, compound2×

Product 1

HCID 56640713HCID 56640713, compoundYield 36%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Compound 96 was synthesized from ethyl 3-{2-(cyanomethoxy)-4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate (Intermediate 134, 0.1 g, 0.199 mmol) and Pd—C (0.02 g), followed by hydrolysis described in scheme 16 (0.005 g, yield: 36.0%); Purity: 93.97%.

Workup

  1. customfollowed by hydrolysis

Sources & evidence

ORD record
ord-a892c38b73c440a68006d3a9096bc7c7
Source dataset
uspto-grants-2016_03
Patent number
US09278915B2

Reaction notes

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