Methyl 3-cyano-3-(4-hydroxyphenyl)propanoate → 3-Cyano-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid
Reaction equation
[CH3:1][O:2]/[N:3]=[C:4](\[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)/[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][OH:14])=[CH:9][CH:8]=1.[C:21]([CH:23]([C:29]1[CH:34]=[CH:33][C:32](O)=[CH:31][CH:30]=1)[CH2:24][C:25]([O:27]C)=[O:26])#[N:22]>>[C:21]([CH:23]([C:29]1[CH:34]=[CH:33][C:32]([O:14][CH2:13][C:10]2[CH:11]=[CH:12][C:7]([O:6][CH2:5]/[C:4](=[N:3]/[O:2][CH3:1])/[C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:8][CH:9]=2)=[CH:31][CH:30]=1)[CH2:24][C:25]([OH:27])=[O:26])#[N:22]Participants
3
Procedure
Compound 98 was synthesized from (4-{[(2E)-2-(methoxyimino)-2-phenylethyl]oxy}phenyl)methanol (0.55 g, 2.03 mmol) and methyl 3-cyano-3-(4-hydroxyphenyl)propanoate (0.46 g, 2.22 mmol) by following the procedure described in scheme 5 (0.008 g, yield: 30.1%); Purity: 93.18%.
Sources & evidence
- ORD record
- ord-3e0ff7e1f39245ecb2d0b7c2f9992cfb
- Source dataset
- uspto-grants-2016_03
- Patent number
- US09278915B2
Reaction notes
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