Methyl 3-cyano-3-(4-hydroxyphenyl)propanoate → 3-Cyano-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid

Participants

Role	Name	HCID	Charge
Reactant	Methyl 3-cyano-3-(4-hydroxyphenyl)propanoate	HCID 66685605	—
Reactant	(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}phenyl)methanol	HCID 86695724	—
Product	3-Cyano-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid	HCID 56640356	30.1%

Reaction Steps

Compound 98 was synthesized from (4-{[(2E)-2-(methoxyimino)-2-phenylethyl]oxy}phenyl)methanol (0.55 g, 2.03 mmol) and methyl 3-cyano-3-(4-hydroxyphenyl)propanoate (0.46 g, 2.22 mmol) by following the procedure described in scheme 5 (0.008 g, yield: 30.1%); Purity: 93.18%.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09278915B2
Source dataset	uspto-grants-2016_03
ORD ID	ord-3e0ff7e1f39245ecb2d0b7c2f9992cfb
Source note	uspto-grants-2016_03