HCID 86695786, compound → HCID 66685529, compound

HRID 922305Notes

Reaction equation

HRID 922305 reaction equation
[O:1]=[C:2]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[CH2:3][O:4][C:5]1[CH:25]=[CH:24][C:8]([CH2:9][O:10][C:11]2[N:16]=[CH:15][C:14](/[CH:17]=[CH:18]/[C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:13][CH:12]=2)=[CH:7][CH:6]=1>C(O)C.C(OCC)(=O)C.[C].[Pd]>[O:1]=[C:2]([C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1)[CH2:3][O:4][C:5]1[CH:25]=[CH:24][C:8]([CH2:9][O:10][C:11]2[N:16]=[CH:15][C:14]([CH2:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:13][CH:12]=2)=[CH:7][CH:6]=1

Participants

4

Reactant 1

HCID 86695786HCID 86695786, compound

Product 1

HCID 66685529HCID 66685529, compoundYield 95%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 21584252Ethanol ethylacetateSolvent

Procedure

A solution of ethyl (2E)-3-(6-{[4-(2-oxo-2-phenylethoxy)benzyl]oxy}pyridin-3-yl)prop-2-enoate (0.13 g, 0.31 mmol) in ethyl acetate ethanol mixture was degassed well and added palladium carbon (10 mg), and stirred under hydrogen bladder for 3 hrs. Reaction mass was filtered through celite pad and concentrated to a colourless oil (0.12 g, Yield: 95%); MS (ESI, 120 eV): m/z=420 (M+H)+.

Workup

  1. customReaction mass
  2. filtrationwas filtered through celite pad

Sources & evidence

ORD record
ord-fa598382560249a3853549ce346e4f62
Source dataset
uspto-grants-2016_03
Patent number
US09278915B2

Reaction notes

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