Ethyl 2-(4-hydroxyphenoxy)acetate → 2-[4-[[4-[(2Z)-2-methoxyimino-2-phenylethoxy]phenyl]methoxy]phenoxy]acetic acid

HRID 922317Notes

Reaction equation

HRID 922317 reaction equation
[CH3:1][O:2]/[N:3]=[C:4](/[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)\[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][OH:14])=[CH:9][CH:8]=1.O[C:22]1[CH:34]=[CH:33][C:25]([O:26][CH2:27][C:28]([O:30]CC)=[O:29])=[CH:24][CH:23]=1>>[CH3:1][O:2]/[N:3]=[C:4](/[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)\[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][O:14][C:22]2[CH:34]=[CH:33][C:25]([O:26][CH2:27][C:28]([OH:30])=[O:29])=[CH:24][CH:23]=2)=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 13187337Ethyl 2-(4-hydroxyphenoxy)acetateHCID 86695770(4-{[(2E)-2-(methoxyimino)-2-phenylethyl]oxy}phenyl)methanol

Product 1

HCID 885830402-[4-[[4-[(2Z)-2-methoxyimino-2-phenylethoxy]phenyl]methoxy]phenoxy]acetic acidYield 13.72%

Procedure

Compound 117 was synthesized from Intermediate 13 (0.22 g, 1.020 mmol) and ethyl (4-hydroxyphenoxy)acetate (0.20 g, 1.020 mmol) by following the procedure described in scheme 41 (0.060 g, yield: 13.72%); Purity: 97.98%.

Sources & evidence

ORD record
ord-3efc166e44cc4582bf80489697961167
Source dataset
uspto-grants-2016_03
Patent number
US09278915B2

Reaction notes

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