(2R)-4-((tert-butoxy)carbonyl)morpholine-2-carboxylic acid → HCID 89939690, compound

HRID 922428Notes

Reaction equation

HRID 922428 reaction equation
[CH:1]1([NH:4][CH:5]([C:7]2[CH:8]=[C:9]([C:15]#[C:16][CH2:17][NH:18][C:19](=[O:22])[O:20][CH3:21])[C:10]([O:13][CH3:14])=[N:11][CH:12]=2)[CH3:6])[CH2:3][CH2:2]1.[C:23]([O:27][C:28]([N:30]1[CH2:35][CH2:34][O:33][C@@H:32]([C:36](O)=[O:37])[CH2:31]1)=[O:29])([CH3:26])([CH3:25])[CH3:24]>>[CH:1]1([N:4]([CH:5]([C:7]2[CH:12]=[N:11][C:10]([O:13][CH3:14])=[C:9]([C:15]#[C:16][CH2:17][NH:18][C:19]([O:20][CH3:21])=[O:22])[CH:8]=2)[CH3:6])[C:36]([C@@H:32]2[O:33][CH2:34][CH2:35][N:30]([C:28]([O:27][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:29])[CH2:31]2)=[O:37])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 6559076(2R)-4-((tert-butoxy)carbonyl)morpholine-2-carboxylic acidHCID 89939691Methyl (3-(5-(1-(cyclopropylamino)ethyl)-2-methoxypyridin-3-yl)prop-2-yn-1-yl)carbamate

Product 1

HCID 89939690HCID 89939690, compound

Procedure

Methyl (3-{5-[1-(cyclopropylamino)ethyl]-2-methoxypyridin-3-yl}prop-2-yn-1-yl)carbamate and (2R)-4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid were treated in the similar manner to Example 162 to give tert-butyl (2R)-2-({cyclopropyl[1-(6-methoxy-5-{3-[(methoxycarbonyl)amino]prop-1-yn-1-yl}pyridin-3-yl)ethyl]amino}carbonyl)morpholine-4-carboxylate [Ex(296-4)] as a colorless oil.

Sources & evidence

ORD record
ord-27333e330cd2436984eafb6275fdbedd
Source dataset
uspto-grants-2016_03
Patent number
US09278944B2

Reaction notes

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