(2R)-4-((tert-butoxy)carbonyl)morpholine-2-carboxylic acid → HCID 89939690, compound

Participants

Role	Name	HCID	Charge
Reactant	(2R)-4-((tert-butoxy)carbonyl)morpholine-2-carboxylic acid	HCID 6559076	—
Reactant	Methyl (3-(5-(1-(cyclopropylamino)ethyl)-2-methoxypyridin-3-yl)prop-2-yn-1-yl)carbamate	HCID 89939691	—
Product	HCID 89939690	HCID 89939690	—

Reaction Steps

Methyl (3-{5-[1-(cyclopropylamino)ethyl]-2-methoxypyridin-3-yl}prop-2-yn-1-yl)carbamate and (2R)-4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid were treated in the similar manner to Example 162 to give tert-butyl (2R)-2-({cyclopropyl[1-(6-methoxy-5-{3-[(methoxycarbonyl)amino]prop-1-yn-1-yl}pyridin-3-yl)ethyl]amino}carbonyl)morpholine-4-carboxylate [Ex(296-4)] as a colorless oil.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09278944B2
Source dataset	uspto-grants-2016_03
ORD ID	ord-27333e330cd2436984eafb6275fdbedd
Source note	uspto-grants-2016_03