Trifluoroacetic acid → HCID 89939599, compound

HRID 922431Notes

Reaction equation

HRID 922431 reaction equation
C(OC([N:8]([CH:26]1[CH2:28][CH2:27]1)[CH:9]([C:11]1[CH:16]=[C:15]([CH:17]=[CH2:18])[N:14]=[C:13](/[CH:19]=[CH:20]/[NH:21][C:22](=[O:25])[O:23][CH3:24])[CH:12]=1)[CH3:10])=O)(C)(C)C.FC(F)(F)C(O)=O>>[CH:26]1([NH:8][CH:9]([C:11]2[CH:16]=[C:15]([CH:17]=[CH2:18])[N:14]=[C:13](/[CH:19]=[CH:20]/[NH:21][C:22](=[O:25])[O:23][CH3:24])[CH:12]=2)[CH3:10])[CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68310410HCID 68310410, compound

Product 1

HCID 89939599HCID 89939599, compound

Procedure

Methyl [(E)-2-(4-{1-[(tert-butoxycarbonyl)(cyclopropyl)amino]ethyl}-6-vinylpyridin-2-yl)vinyl]carbamate and trifluoroacetic acid were treated in the similar manner to Reference Example 113(8) to give methyl ((E)-2-{4-[1-(cyclopropylamino)ethyl]-6-vinylpyridin-2-yl}vinyl)carbamate [Ex(297-5)] as a pale yellow oil.

Sources & evidence

ORD record
ord-177fb24fd87e4ce1becf072aed81c4f8
Source dataset
uspto-grants-2016_03
Patent number
US09278944B2

Reaction notes

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