反应详情

To a solution of 1-(1H-indazol-3-yl)ethanone (5.0 g) and triethylamine (6.53 mL) in chloroform (80 mL) was added dropwise a solution of methyl chlorocarbonate (3.24 g) in chloroform (20 mL) under ice-cooling over 1 hour, and the mixture was stirred at room temperature for 14 hours. The reaction solution was washed with aqueous saturated sodium chloride solution, dried over magnesium sulfate, and then concentrated tinder reduced pressure. The resulting residue was triturated with n-hexane to give methyl 3-acetyl-1H-indazole-1-carboxylate) [REx(101-1)] (6.67 g) as a colorless powder.

1. temperaturecooling over 1 hour
2. washThe reaction solution was washed with aqueous saturated sodium chloride solution
3. dry with materialdried over magnesium sulfate
4. concentrationconcentrated tinder reduced pressure
5. customThe resulting residue was triturated with n-hexane