Methyl(3-bromopropyl)carbamate → Methyl (3-(3-iodo-6-methyl-1H-pyrazolo[3,4-b]pyridin-1-yl)propyl)carbamate

HRID 922468Notes

Reaction equation

HRID 922468 reaction equation
[I:1][C:2]1[C:10]2[C:5](=[N:6][C:7]([CH3:11])=[CH:8][CH:9]=2)[NH:4][N:3]=1.Br[CH2:13][CH2:14][CH2:15][NH:16][C:17](=[O:20])[O:18][CH3:19]>>[I:1][C:2]1[C:10]2[C:5](=[N:6][C:7]([CH3:11])=[CH:8][CH:9]=2)[N:4]([CH2:13][CH2:14][CH2:15][NH:16][C:17](=[O:20])[O:18][CH3:19])[N:3]=1

Participants

3

Reactant 2

HCID 254236Methyl(3-bromopropyl)carbamateHCID 178422879HCID 178422879, compound

Product 1

HCID 68309959Methyl (3-(3-iodo-6-methyl-1H-pyrazolo[3,4-b]pyridin-1-yl)propyl)carbamate

Procedure

3-Iodo-6-methyl-1H-pyrazolo[3,4-b]pyridine and methyl (3-bromopropyl)carbamate were treated in the similar manner to Reference Example 102(1) to give methyl [3-(3-iodo-6-methyl-1H-pyrazolo[3,4-b]pyridin-1-yl)propyl]carbamate [REx(104-3)] as a colorless powder.

Sources & evidence

ORD record
ord-d0b1b78c72654bfdad207d88f651c119
Source dataset
uspto-grants-2016_03
Patent number
US09278944B2

Reaction notes

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