Hydrochloric Acid → HCID 86729914, compound

HRID 922547Notes

Reaction equation

HRID 922547 reaction equation
[C:1]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([C@@H:16]2[CH2:18][C@H:17]2[C:19]([O:21]CC)=[O:20])=[CH:12][C:11]=1[CH3:24])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].Cl>C(O)C>[C:1]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([C@@H:16]2[CH2:18][C@H:17]2[C:19]([OH:21])=[O:20])=[CH:12][C:11]=1[CH3:24])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86729912HCID 86729912, compound

Product 1

HCID 86729914HCID 86729914, compoundYield 49%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

To a solution of ethyl trans-2-[4-(benzoylamino)-3-methylphenyl]cyclopropanecarboxylate (1.29 g) in ethanol (7.98 mL) was added 1N aqueous sodium hydroxide solution (7.98 mL). The reaction mixture was stirred at 50° C. for 6.5 hr, 1N hydrochloric acid (10 mL) was added under ice-cooling, and the mixture was stirred under ice-cooling for 1 hr. The precipitate was collected by filtration to give the title compound (576.9 mg).

Workup

  1. temperaturecooling
  2. stirringthe mixture was stirred under ice-
  3. temperaturecooling for 1 hr
  4. filtrationThe precipitate was collected by filtration

Sources & evidence

ORD record
ord-1fafd8c9002d47bd8741b3ed3c97a617
Source dataset
uspto-grants-2016_03
Patent number
US09278931B2

Reaction notes

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