Potassium Cation → 6-chloro-3-[1-[[5-(4-fluorophenyl)oxolan-3-yl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one

HRID 92269Notes

Reaction equation

HRID 92269 reaction equation
[C:32](=[O:33])([O-:34])[O-:35].[CH3:39][N:40]([CH3:41])[CH:42]=[O:43].[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[O:9][CH2:10][CH:11]([CH2:13][I:14])[CH2:12]2)[cH:6][cH:7]1.[K+:36].[K+:37].[NH:15]1[CH2:16][CH2:17][CH:18]([n:21]2[c:22](=[O:31])[nH:23][c:24]3[c:25]2[cH:26][cH:27][c:28]([Cl:30])[cH:29]3)[CH2:19][CH2:20]1.[OH2:38]>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[O:9][CH2:10][CH:11]([CH2:13][N:15]3[CH2:16][CH2:17][CH:18]([n:21]4[c:22](=[O:31])[nH:23][c:24]5[c:25]4[cH:26][cH:27][c:28]([Cl:30])[cH:29]5)[CH2:19][CH2:20]3)[CH2:12]2)[cH:6][cH:7]1

Participants

7

Reactant 6

HCID 813Potassium Cation2×HCID 962WaterHCID 6228DimethylformamideHCID 19660Carbonate IonHCID 1046075-Chloro-1,3-dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-oneHCID 131514992-(4-Fluorophenyl)-4-(iodomethyl)tetrahydrofuran

Product 1

HCID 131515136-chloro-3-[1-[[5-(4-fluorophenyl)oxolan-3-yl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one

Sources & evidence

ORD record
ord-d8ac4cacdc464da7bb6d61c9fb9bf453
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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