反应详情

Dimethyl(2E)-2-[2-fluoro-3-methylphenyl)imino]butanedioate (7-6, 3.27 g, 12.24 mmol) in DMA (24.47 ml) was heated at 240° C. in the microwave for 5 min. The solvent was evaporated under reduced pressure and the residue triturated with ether to afford a tan solid. The desired product was filtered off and washed with ether till the ether ran colorless affording Methyl 8-fluoro-7-methyl-4-oxo-1,4-dihydroquinoline-2-carboxylate (7-7, 1.23 g, 43% yield) as a tan solid, LCMS shows 93% pure, LRMS m/z (M+H)+ 236.1 found, 236.1 required.

1. customThe solvent was evaporated under reduced pressure
2. customthe residue triturated with ether
3. customto afford a tan solid
4. filtrationThe desired product was filtered off
5. washwashed with ether till the ether