Hydrochloric Acid → Amantadine

HRID 922821노트

반응식

C[C:2]12[CH2:11][C:9]3([NH2:12])[CH2:10][CH:4]([CH2:5][C:6](C)([CH2:8]3)[CH2:7]1)[CH2:3]2.Cl.Cl>>[C:9]12([NH2:12])[CH2:10][CH:4]3[CH2:3][CH:2]([CH2:7][CH:6]([CH2:5]3)[CH2:8]1)[CH2:11]2

참가 물질

반응물 2

HCID 313Hydrochloric Acid

HCID 181458Memantine Hydrochloride

생성물 1

HCID 2130Amantadine수율 5%

실험 절차

In a manner similar to the preparation of the compound of formula DC in Example 13, the compound of formula SA was prepared except that the compound of formula EC was used in place of the compound of formula DB and memantine hydrochloride (i.e., the hydrochloride of 1-amine-3,5-dimethyl-adamantane, Sigma-Aldrich) was used in place of 1-adamantylamine (yield 5%).

후처리

customIn a manner similar to the preparation of the compound of formula DC in Example 13
customthe compound of formula SA was prepared except that the compound of formula EC

출처 및 근거

ORD 기록: ord-fc374a625cdb41e8912b087166c6efcb
출처 데이터셋: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09278967B2

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