Iodoethane → HCID 58614681, compound

HRID 922882Notes

Reaction equation

HRID 922882 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:21])[C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[N:12][C:11]=2[CH3:20])=[CH:4][C:3]=1[C:22]1[CH:27]=[CH:26][C:25]([OH:28])=[CH:24][N:23]=1.I[CH2:30][CH3:31]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:21])[C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:17])([F:19])[F:18])=[N:12][C:11]=2[CH3:20])=[CH:4][C:3]=1[C:22]1[CH:27]=[CH:26][C:25]([O:28][CH2:30][CH3:31])=[CH:24][N:23]=1

Participants

3

Reactant 2

HCID 6340IodoethaneHCID 58614938HCID 58614938, compound

Product 1

HCID 58614681HCID 58614681, compound

Procedure

N-(4-chloro-3-(5-hydroxypyridin-2-yl)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide (0.05 mmol) was used in Procedure L with excess iodoethane. Purified by silica gel chromatography (0-100% ethyl acetate/hexane) to yield N-(4-chloro-3-(5-ethoxypyridin-2-yl)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide as a white solid: TLC Rf=0.64 (50% ethyl acetate/hexanes); MS (Q1) 436 (M)+.

Workup

  1. customPurified by silica gel chromatography (0-100% ethyl acetate/hexane)

Sources & evidence

ORD record
ord-8b8ab458ed684b99abcc2ec3a6215f48
Source dataset
uspto-grants-2016_03
Patent number
US09278961B2

Reaction notes

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