Diethylammonium chloride → HCID 58614796, compound

HRID 922925Notes

Reaction equation

HRID 922925 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[C:11](=[O:26])[NH:12][C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[C:15]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=2)[CH:14]=1)[C:5](O)=[O:6].Cl.[CH2:28]([NH:30][CH2:31][CH3:32])[CH3:29]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:5]([N:30]([CH2:31][CH3:32])[CH2:28][CH3:29])=[O:6])[CH:8]=[CH:9][C:10]=1[C:11]([NH:12][C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[C:15]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=2)[CH:14]=1)=[O:26]

Participants

3

Reactant 2

HCID 10197650Diethylammonium chlorideHCID 668786053-Chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid

Product 1

HCID 58614796HCID 58614796, compound

Procedure

75 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to diethylamine hydrochloride via Procedure G. The product was purified on reverse phase HPLC to yield 2-chloro-N1-(4-chloro-3-(pyridin-2-yl)phenyl)-N4,N4-diethylterephthalamide. MS (Q1) 443 (M)+

Workup

  1. customThe product was purified on reverse phase HPLC

Sources & evidence

ORD record
ord-35e449c4e66047c8a1d7990fcb51577b
Source dataset
uspto-grants-2016_03
Patent number
US09278961B2

Reaction notes

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