5-Amino-2-chloropyridine → HCID 58614676, compound

HRID 922973Notes

Reaction equation

HRID 922973 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[C:11](=[O:26])[NH:12][C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[C:15]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=2)[CH:14]=1)[C:5]([OH:7])=O.[Cl:27][C:28]1[N:33]=[CH:32][C:31]([NH2:34])=[CH:30][CH:29]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:5]([NH:34][C:31]2[CH:32]=[N:33][C:28]([Cl:27])=[CH:29][CH:30]=2)=[O:7])[CH:8]=[CH:9][C:10]=1[C:11]([NH:12][C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[C:15]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=2)[CH:14]=1)=[O:26]

Participants

3

Reactant 2

HCID 793055-Amino-2-chloropyridineHCID 668786053-Chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid

Product 1

HCID 58614676HCID 58614676, compound

Procedure

50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 6-chloropyridin-3-amine via Procedure G. The crude product was purified on reverse phase HPLC to yield 2-chloro-N1-(4-chloro-3-(pyridin-2-yl)phenyl)-N4-(6-chloropyridin-3-yl)terephthalamide. MS (Q1) 497 (M)+.

Workup

  1. customThe crude product was purified on reverse phase HPLC

Sources & evidence

ORD record
ord-cc1620fcdc0c40a789173447a449a326
Source dataset
uspto-grants-2016_03
Patent number
US09278961B2

Reaction notes

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