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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 923008Generated: October 31, 2026

3-(Methanesulfonylmethyl)benzoic acid → HCID 58614934, compound

https://huagongshe.com/reaction/923008

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Methanesulfonylmethyl)benzoic acidHCID 4962583—
Reactant4-Chloro-3-(pyridin-2-yl)anilineHCID 40151925—
ProductHCID 58614934HCID 58614934—

Reaction Steps

300 mg of methyl 3-(bromomethyl)benzoate was reacted via Procedure O to give methyl 3-(methylsulfonylmethyl)benzoate. 230 mg of methyl 3-(methylsulfonylmethyl)benzoate was reacted via Procedure M to give 3-(methylsulfonylmethyl)benzoic acid. 75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 3-(methylsulfonylmethyl)benzoic acid via Procedure G. The crude product was purified by reverse phase HPLC to yield pure N-(4-chloro-3-(pyridin-2-yl)phenyl)-3-(methylsulfonylmethyl)benzamide. MS (Q1) 401 (M)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09278961B2
Source datasetuspto-grants-2016_03
ORD IDord-02467c5bcbea4fefa64f6a054754aef0
Source noteuspto-grants-2016_03