HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl methylphosphonite → HCID 58614760, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl methylphosphonite | HCID 85063 | — |
| Reactant | 4-(Bromomethyl)-N-[4-chloro-3-(2-pyridinyl)phenyl]benzamide | HCID 66878170 | — |
| Product | HCID 58614760 | HCID 58614760 | — |
Reaction Steps
90 mg of 4-(bromomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide was reacted with 45 μL of diethyl methylphosphonite in the microwave at 120° C. for 5 minutes. The reaction was evaporated to dryness and purified by reverse phase HPLC to give pure ethyl 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzyl(methyl)phosphinate. MS (Q1) 429 (M)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278961B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-15ee266f798c4eb88ce86c62970faf01 |
| Source note | uspto-grants-2016_03 |