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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 923043Generated: October 30, 2026

Hydrochloric Acid → HCID 58614830, compound

https://huagongshe.com/reaction/923043

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant4-({1-[(Tert-butoxy)carbonyl]piperidin-4-yl}methyl)benzoic acidHCID 11522607—
Reactant4-Chloro-3-(pyridin-2-yl)anilineHCID 40151925—
Solvent1,4-DioxaneHCID 31275—
ProductHCID 58614830HCID 58614830—

Reaction Steps

75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 125 mg of 4-((1-(tert-butoxycarbonyl)piperidin-4-yl)methyl)benzoic acid via Procedure G. The crude product was treated with 4N HCl in Dioxane, evaporated and purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(piperidin-4-ylmethyl)benzamide. MS (Q1) 406.1 (M)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09278961B2
Source datasetuspto-grants-2016_03
ORD IDord-7773886595964e04b103c9b3b1b58c13
Source noteuspto-grants-2016_03