Hydrochloric Acid → HCID 58614830, compound

HRID 923043Notes

Reaction equation

HRID 923043 reaction equation
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1.C(OC([N:22]1[CH2:27][CH2:26][CH:25]([CH2:28][C:29]2[CH:37]=[CH:36][C:32]([C:33](O)=[O:34])=[CH:31][CH:30]=2)[CH2:24][CH2:23]1)=O)(C)(C)C.Cl>O1CCOCC1>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:33](=[O:34])[C:32]2[CH:31]=[CH:30][C:29]([CH2:28][CH:25]3[CH2:24][CH2:23][NH:22][CH2:27][CH2:26]3)=[CH:37][CH:36]=2)=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 115226074-({1-[(Tert-butoxy)carbonyl]piperidin-4-yl}methyl)benzoic acidHCID 401519254-Chloro-3-(pyridin-2-yl)aniline

Product 1

HCID 58614830HCID 58614830, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 125 mg of 4-((1-(tert-butoxycarbonyl)piperidin-4-yl)methyl)benzoic acid via Procedure G. The crude product was treated with 4N HCl in Dioxane, evaporated and purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(piperidin-4-ylmethyl)benzamide. MS (Q1) 406.1 (M)+.

Workup

  1. customevaporated
  2. custompurified by reverse phase HPLC

Sources & evidence

ORD record
ord-7773886595964e04b103c9b3b1b58c13
Source dataset
uspto-grants-2016_03
Patent number
US09278961B2

Reaction notes

Loading…