HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-methanesulfonamidobenzoic acid → 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonamido)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-methanesulfonamidobenzoic acid | HCID 18350497 | — |
| Reactant | 4-Chloro-3-(pyridin-2-yl)aniline | HCID 40151925 | — |
| Reactant | Methyl 2-chloro-4-(methylsulfonamido)benzoate | HCID 54238017 | — |
| Product | 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonamido)benzamide | HCID 52948347 | — |
Reaction Steps
4.2 g of methyl 2-chloro-4-(methylsulfonamido)benzoate was hydrolyzed via Procedure M. 1 g of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 1.35 g of 2-chloro-4-(methylsulfonamido)benzoic acid via Procedure G. The crude product was purified by reverse phase HPLC to yield 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonamido)benzamide. MS (Q1) 436.1 (M)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278961B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-4ee8fd0de1624ebf98cf721fabbbc037 |
| Source note | uspto-grants-2016_03 |